Effect of Intermittent Hypoxia on Ventilatory Endurance in Healthy Volunteers

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Sleep apnoea syndrome is a common disorder responsible for poor sleep quality and repeated oxygen depletion in the blood. Patients suffering from this disease experience a reduction in their endurance, i.e. their ability to make prolonged efforts. This loss of muscular endurance affects breathing in particular. It is known that poor sleep reduces endurance, but it is not knwon whether the repeated lack of oxygen for several hours at night also has this effect. This information could help improve the management of certain acute respiratory illnesses (asthma attacks, respiratory infections, etc.). This project therefore seeks to establish a link between repeated oxygen deprivation and a reduction in the human brain's ability to train respiratory muscles. To this end, the healthy volunteers in this study will perform the same breathing exercise (breathing for as long as possible through a mask that makes inspiration difficult) twice: once after 6 hours' exposure to repeated oxygen deprivation, and once under conditions of normal oxygenation. The order of these exercises will be randomized. These exercises will take place in a special room, a hypoxia chamber, where it is possible to deplete the air breathed in oxygen.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 40
Healthy Volunteers: t
View:

• Non-excessive coffee drinker (\< 3 espressos / day)

• Non-smoker or weaned for 3 months and total consumption \< 10 packs/year

• With a BMI within \]18 - 25\[ kg/m².

• Benefiting from a Social Security plan or benefiting from one through a third party

• Giving free, informed and signed consent, after receiving clear and fair information about the study.

Locations
Other Locations
France
CHU Poitiers
RECRUITING
Poitiers
Contact Information
Primary
Christophe RAULT, Md-PhD
christophe.rault@chu-poitiers.fr
+33549445348
Backup
Quentin HERAUD, BS
quentin.heraud@chu-poitiers.fr
Time Frame
Start Date: 2025-01-16
Estimated Completion Date: 2026-11
Participants
Target number of participants: 23
Treatments
Experimental: Groupe 1
Control visit in normoxia at V1 and then test visit in intermittent hypoxia at V2
Experimental: Groupe 2
Test visit in intermittent hypoxia at V1 and then control visit in normoxia at V2
Related Therapeutic Areas
Sponsors
Leads: Poitiers University Hospital

This content was sourced from clinicaltrials.gov